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目的 分析耐多药肺结核病人采用以 OK- 4 32 ,立复欣 ,左氧氟沙星为主的综合化疗方案治疗的近期疗效。 方法 对 2 0 0 1年 1月～ 2 0 0 2年 1月住院的 31例耐多药肺结核病人采用以 OK- 4 32 ,立复欣 ,左氧氟沙星为主、结合结核药敏试验加用其他敏感药物的化疗方案进行治疗。实施方案 :3DRSVAKVZE/ 6 DVZE+OK- 4 32。 3、6、9月末复查痰厚涂片找抗酸杆菌及胸片 ,每月复查肝肾功能及血常规 ,治疗前及疗程末分别检测 T细胞亚群。 结果 痰菌阴转情况 :3月末阴转 30例 (96 .7% ) ,6月末阴转 2 9例 (93.5 % ) ,疗程末 (9月末 )阴转 2 9例 (93.7% ) ;T细胞亚群检测 :CD4 / CD8治疗后明显高于治疗前 (P<0 .0 1) ;肝损害 1例 ,过敏性皮炎 1例 ,药物热 1例。 结论 该治疗方案近期疗效满意 ,药物副反应小 ,病人容易耐受 ,值得临床推广
Objective To analyze the short-term effect of multidrug-resistant pulmonary tuberculosis (TB) patients treated with a combination chemotherapy regimen consisting of OK-4 32, Li-Fu Xin and levofloxacin. Methods 31 patients with multidrug-resistant pulmonary tuberculosis who were admitted to hospital from January 2001 to January 2002 were treated with OK- 4 32, Li-Fu-Xin and levofloxacin, combined with antimicrobial susceptibility test plus other sensitivities Drug chemotherapy regimens for treatment. Implementation: 3DRSVAKVZE / 6 DVZE + OK- 4 32. 3, 6, 9 at the end of review thick sputum smear to find acid-fast bacilli and chest X-ray, liver and kidney function and blood routine examination every month before treatment and the end of treatment were detected T cell subsets. Results The sputum negative conversion rate was 30 (96.7%) at the end of March, 29 (93.5%) at the end of June, and 29 (93.7%) at the end of the treatment (at the end of September) Subgroup detection: CD4 / CD8 after treatment was significantly higher than before treatment (P <0 01); liver damage in 1 case, allergic dermatitis in 1 case, drug fever in 1 case. Conclusion The curative effect of this treatment is satisfactory in the near future. The side effects of the drug are small and the patient is easy to tolerate, which is worthy of clinical promotion