药物化学及其稳定性巴比土类是取代的嘧啶衍生物。这类药物共有的基本结构为丙二酸与脲的缩合物——巴比土酸,后者对中枢神经系统并无活性作用。但以烷基、烯烃基和/或芳基取代其五位碳上的二个氢原子后,就生成对中枢神经系统有作用的化合物。巴比土酸的其它取代物有:硫巴比土类和N-甲基巴比土类。 Medicinal Chemistry and Its Stability Barbiturates are substituted pyrimidine derivatives. The basic structure common to these drugs is the malonic acid and urea condensate - barbituric acid, which has no activity on the central nervous system. However, the replacement of two hydrogen atoms at the five carbons with an alkyl group, an alkene group and / or an aryl group generates a compound having an effect on the central nervous system. Other substitutes for barbituric acid are: sulfur barbiturates and N-methyl barbiturates.