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p16基因对肺癌的发生和发展有重要的影响,p16在肺癌组织中表达失活的主要原因是启动子区的高甲基化,本研究是p16基因的分子生物学特性以及它和肺癌的关系的综述。
The p16 gene has an important influence on the occurrence and development of lung cancer. The main reason of the inactivation of p16 in lung cancer is the hypermethylation of the promoter region. This study is a review of the molecular biology of p16 gene and its relationship with lung cancer .