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目的探讨子宫内膜癌中血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达及其与临床病理学之间的关系。方法应用免疫组织化学方法检测60例子宫内膜癌组织、25例子宫内膜非典型增生组织和25例正常子宫内膜组织中的VEGF蛋白的表达及微血管密度(micro-vessel density,MVD)。结果子宫内膜癌组织的VEGF阳性表达率为65%,VEGF蛋白表达及MVD在子宫内膜癌组织中均显著高于子宫内膜非典型增生组织及正常子宫内膜组织(P<0.05);子宫内膜癌组VEGF表达与肿瘤分化程度、淋巴结转移、浸润肌层深度、病理分期密切相关(P<0.05),而与患者的年龄、肿瘤直径无关(P>0.05)。结论 VEGF的表达在子宫内膜癌的发生、发展中起重要作用,有望作为子宫内膜癌抗血管治疗的靶标。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in endometrial carcinoma and its relationship with clinicopathology. Methods Immunohistochemical method was used to detect the expression of VEGF protein and micro-vessel density (MVD) in 60 cases of endometrial carcinoma, 25 cases of endometrial dysplasia and 25 cases of normal endometrium. Results The positive rate of VEGF in endometrial carcinoma was 65%. The expression of VEGF and MVD in endometrial carcinoma were significantly higher than those in endometrial dysplasia and normal endometrium (P <0.05). The expression of VEGF in endometrial carcinoma was closely related to tumor differentiation, lymph node metastasis, depth of myometrial invasion, and pathological stage (P <0.05), but not to age and tumor diameter (P> 0.05). Conclusion The expression of VEGF plays an important role in the occurrence and development of endometrial carcinoma and is expected to be the target of anti-vascular therapy for endometrial cancer.