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本文报告一例服奎宁自杀急性中毒者的血液和脏器内的奎宁浓度。该例为女性,18岁,体重51公斤,在服用硫酸奎宁20片(300毫克/片)3小时后出现中毒,经洗胃尚找出若干残余药片。患者先出现嗜睡和抽搐,不久出现惊厥和意识消失。虽采取一切治疗如腹膜透析和对症处理但均无效,于24小时后死亡。每隔2小时测定一次奎宁的血浓度。第4小时为11毫克/升,至死亡时为6毫克/升(尸检标本)。奎宁在体内迅速代谢,并在24小时内从尿中完全排出。从该患者奎宁血浓度缓慢下降提示,尽管经过洗胃,但肠道仍继续吸收奎宁。
This article reports the quinine concentration in the blood and organs of a person who succumbed to an acute poisoning of quinine. The case was female, 18 years old and weighed 51 kg. Toxicosis occurred after taking 20 doses of quinine sulphate (300 mg / tablet) for 3 hours. Several residual tablets were still found after gastric lavage. Patients first appear drowsiness and convulsions, soon convulsions and loss of consciousness. Despite all the treatment such as peritoneal dialysis and symptomatic treatment but were ineffective, died after 24 hours. The blood concentration of quinine was measured every 2 hours. 11 mg / L at 4 hours and 6 mg / L at death (autopsy specimens). Quinine rapidly metabolises in the body and is completely excreted from the urine within 24 hours. Slow declines in the concentration of quinine in this patient suggest that the intestinal tract continues to absorb quinine despite gastric lavage.