目的探讨电子交叉配血技术在我国临床输血中的可行性与安全性。方法采用全自动血型仪和试管法对患者和献血者进行血型鉴定和抗体筛查。患者和献血者2次血型鉴定结果一致及抗筛试验结果阴性,与传统血清学交叉配血法相符,模拟进行红细胞悬液出库。结果电子交叉配血法与传统血清学交叉配血法结果相符的4435 U红细胞悬液模拟出库给2 330名患者输注,未观察到ABO/RhD血型不合的输血不良反应。电子交叉配血法与传统血清学交叉配血法结果不相符,未模拟出库红细胞悬液65 U。主要原因为患者不规则抗体筛查漏检抗-Mur;患者直接抗球蛋白C3试验阳性需输注洗涤红细胞,患者直接抗球蛋白IgG试验阳性;献血者直接抗球蛋白Ig G试验阳性。结论在完善血型不规则抗体筛查试剂抗原谱和增加患者、献血者直接抗球蛋白试验的基础上,电子交叉配血技术在我国临床输血中具有可行性与安全性。为了临床输血安全,对不符合电子交叉配血条件的应采用血清学交叉配血作为补充。 Objective To investigate the feasibility and safety of electronic cross matching with blood in clinical transfusion in China. Methods The blood type and antibody screening of patients and blood donors were performed by automatic blood analyzer and in vitro test. Patients and donors 2 blood type identification results consistent and anti-screening test results negative, and traditional serological cross-matching blood, simulated red blood cell suspension out of the library. Results The transfusion of 4435 U red blood cell suspension simulating the traditional cross-matching method with the traditional serological method was used to simulate the transfusion of infusions to 2 330 patients. No transfusion adverse reaction was found in the ABO / RhD blood group. Electronic cross-matching method and traditional serology cross matching blood results do not match, not simulated library of red blood cell suspension 65 U. The main reason for the irregular antibody screening missed anti-Mur patients; patients with direct anti-globulin C3 test was positive red blood cells washed transfusion, patients with direct antiglobulin IgG test positive; direct antiglobulin Ig G test positive. Conclusion On the basis of perfecting antigenspectrum of blood group antibody screening reagent and increasing direct antiglobulin test in patients and blood donors, it is feasible and safe to use electronic cross matching technology in clinical blood transfusion of our country. For clinical transfusion safety, do not meet the conditions of electronic cross-matching should be used to supplement serum cross-matching blood.