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【目的】探讨重度颅脑损伤患者能量支持时机选择和影响预后的因素。【方法】选取2010年9月至2012年9月入本院治疗的88例重度颅脑损伤患者（格拉斯哥昏迷评分≤8分）作为研究对象，其中44例重度颅脑损伤患者采用十二指肠置管早期肠内营养作为观察组，另外44例重度颅脑损伤患者采用传统延迟性胃肠内营养的同类患者作为对照组，观察比较两组患者相关的营养指标、并发症发生情况及预后，并进行统计学分析。【结果】重度颅脑损伤患者能从早期的肠内营养途径中获得比较充分的能量和蛋白质合成所必需的营养物质，治疗14 d和28 d观察组血清总蛋白，血清白蛋白等营养指标均优于对照组，且两组相比较差异有显著性（P ＜0．05），观察组并发症发生率低于对照组，预后优于对照组，且两组相比较差异有显著性（P＜0．05）。【结论】重度颅脑损伤患者采用十二指肠置管进行早期肠内营养支持可减少并发症，改善患者预后。“,”[Objective]To explore the selection of the time of energy support in patients with severe cranio-cerebral injury and the influential factors of prognosis .[Methods] Totally 88 patients with severe craniocere-bral injury(GCS≤8) in our hospital from Sept .2010 to Sept .2012 were enrolled in the study .The observa-tion group( n =44) was given early enteral nutrition by duodenal catheter ,while the control group was con-ventional delayed enteral nutrition .Nutrition parameters ,the incidence of complications and prognosis of two groups were observed and compared .Statistical analysis was taken .[Results]The patients with severe cranio-cerebral injury could obtain adequate energy and ingredients for protein synthesis through early enteral nutri-tion .Nutrition parameters such as serum total protein and albumin in observation group at 14d and 28d after treatment were better than those in control group ,and there was significant difference between two groups ( P<0 .05) .The incidence of complications in observation group was lower than that in control group ,but the prognosis of observation group was better than that of control group ,and there was significant difference( P<0 .05) .[Conclusion]Early enteral nutrition support by duodenal catheter for patients with severe craniocere-bral injury can reduce the complications and improve the prognosis of patients .