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脑心通口服液是银杏叶的口服制剂。银杏叶为银杏科银杏属植物银杏Ginkgo biloba L的干燥茎叶。自60年代以来国内外学者对银杏的化学成分、药理作用及其应用作了大量的研究工作。银杏叶中的有效成分为黄酮类、二萜内酯类等。银杏叶中提取的黄酮类化合物用于豚鼠离体心脏灌流,可引起冠状血管扩张、脑血流增加等多样药理活性。现代药理表明,如果能对抗ADP诱导的血小板聚集,使血液粘度降低,延长复钙时间和凝血酶原时间就会防止血栓形成,从而说明该药品具有抗凝及纤溶活性,具有活血化瘀的作用。本文作者选用体外抗ADP诱导血小板聚集,血液粘度测定,复钙时间和凝血酶原时间测定和纤溶活性测定5项活血化瘀药理指标对脑心通口服液进行了测试,结果如下。
Naoxintong Oral Liquid is an oral preparation of Ginkgo biloba leaves. Ginkgo biloba is the dry stem of Ginkgo biloba L. Ginkgo biloba Ginkgo biloba. Since the 1960s, scholars at home and abroad have done a lot of research on the chemical composition, pharmacological effects and applications of Ginkgo biloba. The active ingredients in Ginkgo biloba leaves are flavonoids, diterpene lactones, and the like. The flavonoids extracted from ginkgo biloba leaves can be used for pericardial perfusion of guinea pigs, which can cause coronary vasodilation and increased cerebral blood flow. Modern pharmacology shows that if it can fight ADP-induced platelet aggregation and reduce blood viscosity, prolonging recalcification time and prothrombin time will prevent thrombosis, indicating that the drug has anticoagulant and fibrinolytic activity, with blood circulation effect. The authors used in vitro anti-ADP induced platelet aggregation, blood viscosity measurement, recalcification time and prothrombin time measurement and fibrinolytic activity measured five items of blood circulation pharmacological indicators of Naoxintong oral liquid were tested, the results are as follows.