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本文对３９例ＨＰ（＋），２３例ＨＰ（－）的慢性浅表性胃炎患者及８例正常对照组的胃窦粘膜组织及胃液经胃镜取材后用放射免疫分析方法（ＲＩＡ）分别测定了胃泌素、生长抑素含量。研究结果显示：①胃窦粘膜组织ＳＳ水平在ＨＰ（－）胃炎组显著高于ＨＰ（＋）胃炎组（Ｐ＜０．０１）而与正常组比较无显著性差异（Ｐ＞０．０５）。ＨＰ（＋）胃炎组较正常组ＳＳ水平为低（Ｐ＜０．０５）；②胃液ＳＳ水平在ＨＰ（－）胃炎组显著高于ＨＰ（＋）组（Ｐ＜０．０１）与正常组比无显著性差异（Ｐ＞０．０５）；③胃窦粘膜ＧＳ水平在ＨＰ（＋）组与ＨＰ（－）组及正常组之间比较均无统计学差异（Ｐ＞０．０５），而胃液ＧＳ水平在ＨＰ（＋）组显著高于ＨＰ（－）组（Ｐ＜０．０１）及正常组（Ｐ＜０．０５）；④组织ＳＳ水平与胃液ＳＳ水平呈正相关（ｒ＝０．２９８４，Ｐ＜０．０５），与胃液ＧＳ水平呈负相关（ｒ＝－０．３８６０Ｐ＜０．００１）。研究结果表明，ＨＰ感染胃窦粘膜可致其组织及胃液ＳＳ水平降低，胃液ＧＳ水平增高。提示：ＨＰ感染可能抑制了胃窦Ｄ细胞的功能，ＨＰ感染可使Ｇ细胞的腔分泌功能增强。
In this paper, 39 patients with chronic superficial gastritis of HP (-), 23 patients with chronic gastritis (HP) and 8 normal control group were examined by gastroscope mucosa tissue and gastric juice by radioimmunoassay (RIA) were measured Gastrin, somatostatin content. The results showed that: (1) The SS level of antral mucosa in HP (-) gastritis group was significantly higher than that in HP (+) gastritis group (P <0.01), but not significantly different from that in normal group (P> 0.05) . The level of SS in gastric juice of HP (+) group was lower than that of normal group (P <0.05); ② The level of SS in gastric juice was significantly higher in HP (-) gastritis group than in HP group (P> 0.05). (3) There was no significant difference in the level of GS in antral mucosa between HP (+) group and HP (-) group and normal group (P> 0.05) The level of GS in gastric juice was significantly higher in HP (+) group than that in HP (-) group and normal group (P <0.05). ④ The level of SS in gastric tissue was positively correlated with SS level in gastric juice (r = 0 .2984, P <0.05), but negatively correlated with gastric juice GS level (r = -0.3860 P <0.001). The results showed that HP infection of gastric antral mucosa caused its tissue and gastric juice SS levels decreased, gastric juice GS levels increased. Tip: HP infection may inhibit the function of gastric antral D cells, HP infection can make G cell cavity secretion enhanced.