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应用高效液相色谱(HPLC)法检测49例妊高征尿FPA水平.结果显示:22例轻、中度妊高征尿FPA均值71.65±18.53mg/mg Cr,显著高于正常晚孕妇女(52.21±19.21,P<0.01);15例先兆子痫尿FPA值为146.65±32.53ng/mg Cr,显著高于轻中度妊高征组(P<0.001),12例子痫尿FPA均值为422.93±81.46ng/mg Cr,明显高于先兆子痫组(P<0.001).提示妊高征循环血液处于异常高凝血状态,其严重程度与妊高征的病情轻重相平行.
The FPA levels of 49 patients with PIH were detected by high performance liquid chromatography (HPLC) .The results showed that FPA of 22 mild and moderate PIH were 71.65 ± 18.53mg / mg Cr, significantly higher than that of normal pregnant women 52.21 ± 19.21, P <0.01). The FPA of 15 cases with preeclampsia was 146.65 ± 32.53ng / mg Cr, which was significantly higher than that of mild to moderate pregnancy-induced hypertension (P <0.001). The average FPA of 12 cases with eclampsia was 422.93 ± 81.46ng / mg Cr, significantly higher than those in preeclampsia (P <0.001), suggesting that circulating blood of PIH is abnormally hypercoagulable and its severity is in parallel with the severity of PIH.