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目的:探讨米非司酮在妇产科学中的临床应用,包括其在终止早、中期妊娠,甚至晚期时的效果。方法:选择我院2011年4月到2012年6月收治的妊娠女性148例,包括早期妊娠108例,中期妊30例,晚期妊娠10例。观察米非司酮用于晚期妊娠时的促宫颈成熟、软化宫颈、促进宫颈扩张及产程顺利进行的作用。结果:将米非司酮配伍米索前列醇(MP)运用于98例早期妊娠女性,其中,组织完全排出者76例,有14例复查子宫发现少部分残留,进行简单清宫后取出组织物,终止妊娠的成功率为91.8%;运用于中期妊娠患者30例,胎儿成功娩出例数为26例,成功率为86.7%,术后进行清宫。通过观察米非司酮对晚期妊娠女性的影响,发现米非司酮有利于分娩产妇软化扩张宫颈,促进产程顺利进行。结论:米非司酮配伍米索前列醇在终止妊娠方面具有较好的临床使用效果,大量的临床资料已经证实其安全性,具有比较广阔的发展前景。
Objective: To investigate the clinical application of mifepristone in obstetrics and gynecology, including its effect in terminating early and middle gestational and even advanced stage. Methods: A total of 148 pregnant women were enrolled in our hospital from April 2011 to June 2012, including 108 cases of early pregnancy, 30 cases of middle pregnancy and 10 cases of late pregnancy. To observe the use of mifepristone in advanced pregnancy cervical maturation, softening the cervix and promote cervical dilatation and labor smoothly the role. Results: Mifepristone and misoprostol (MP) were applied to 98 cases of early pregnant women, of which 76 cases were completely discharged from the tissue and 14 cases were found to have a small amount of residue after the examination of the uterus. After a simple curettage, the tissues were removed, The success rate of termination of pregnancy was 91.8%; used in 30 cases of midterm pregnancy, the successful delivery of the fetus in 26 cases, the success rate was 86.7%, after the curettage. By observing the impact of mifepristone on women of late pregnancy, mifepristone found that maternal softening to expand the cervix and promote labor smoothly. Conclusion: Mifepristone combined with misoprostol has better clinical efficacy in terminating pregnancy. A large number of clinical data have confirmed its safety and has a broad development prospect.