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目的观察不同阿奇霉素序贯疗法治疗儿童支原体肺炎疗效。方法 70例支原体肺炎患儿,按照随机数字表法分为对照组和观察组,每组35例。对照组给予阿奇霉素注射剂治疗,静脉滴注连续给药5 d,间隔2 d后,改为口服肠溶胶囊;观察组注射剂和口服剂均为连续应用3 d,停用4 d。治疗2周后,比较两组疗效及不良反应。结果两组总有效率比较差异无统计学意义(P>0.05)。观察组不良反应发生率为25.7%,低于对照组的65.7%(P<0.05);观察组症状改善时间、住院时间均明显短于对照组(P<0.05)。结论连续应用3 d、停用4 d的阿奇霉素序贯疗法治疗儿童支原体肺炎疗效较佳,临床安全性高,可为临床治疗提供方案参考。
Objective To observe the effect of different azithromycin sequential therapy on children with mycoplasma pneumonia. Methods Seventy patients with mycoplasma pneumonia were divided into control group and observation group according to random number table method, with 35 cases in each group. The control group was treated with azithromycin injection. After continuous intravenous infusion for 5 days, the rats in the control group were treated with oral enteric capsules after 2 days. The injection and oral agents in the observation group were administered continuously for 3 days and stopped for 4 days. After 2 weeks of treatment, the efficacy and adverse reactions of the two groups were compared. Results There was no significant difference in total effective rate between the two groups (P> 0.05). The incidence of adverse reactions in the observation group was 25.7%, which was lower than that in the control group (65.7%, P <0.05). The symptom improvement time and hospitalization time in the observation group were significantly shorter than those in the control group (P <0.05). Conclusions Sequential application of azithromycin for 3 days and 3 days after discontinuation of 4-day treatment of children with mycoplasma pneumonia has better curative effect, high clinical safety and can provide a reference for clinical treatment.