This paper is based on an ethnobotanical project carried out in the remote Hindukush mountain region of Swat Kohistan. Most of the local people still rely on medicinal plants for curing different diseases. However, the traditional use and pertinent knowledge of medicinal plants are on decline with the introduction of allopathic drugs in the study area. During present study, an effort was made to document the traditional knowledge of some important medicinal shrubs of Swat Kohistan. The traditional uses of 18 frequently used shrubs belonging to 12 different families were thus documented. The Kohistani people use these medicinal shrubs for curing multiple ailments and some of these are also exported to other parts of Pakistan.