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报告1例乳房外Paget病(EMPD)并发尖锐湿疣(CA)。患者男,72岁。阴茎、阴囊浸润性红斑伴瘙痒4年,1个月前阴茎、阴囊、龟头及包皮出现多个疣状赘生物。皮损组织病理检查:(阴茎根部皮损)表皮棘层肥厚,表皮突延长,表皮内有不等量的Paget细胞,呈圆形或卵圆形,无细胞间桥,胞质丰富,淡染,细胞核较大,伴慢性炎症;(阴茎赘生物)鳞状上皮呈乳头样增生伴挖空样细胞。免疫组化示:CK7(+)、CerbB2(+)、CK5/6(+)、P53(+)、Ki-67约20%(+)、CK20(-)、s-100蛋白(-)及HMB45(-)。诊断:EMPD并发CA。
One case of extramammary Paget’s disease (EMPD) complicated with condyloma acuminatum (CA) was reported. Male patient, 72 years old. Penis, scrotum infiltrative erythema with itching 4 years, 1 month ago the penis, scrotum, glans and foreskin appear multiple verrucous neoplasms. Skin lesions histological examination: (penile root skin lesions) epidermal acanthosis hypertrophy, epidermal protrusion, there are varying degrees of Paget cells in the epidermis, was round or oval, no cell bridge, cytoplasm rich, light Larger nuclei, with chronic inflammation; (penile neoplasms) squamous epithelium was papillary hyperplasia with hollow cells. Immunohistochemistry showed that the expression of CK7 (+), CerbB2 (+), CK5 / 6 (+), P53 (+), Ki-67 about 20% HMB45 (-). Diagnosis: EMPD Concurrent CA.