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目的 :探讨一氧化氮 (NO)和内皮素 (ET)在 2型糖尿病 (NIDDM)患者血浆中变化及临床意义。方法 :采用硝酸盐还原酶比色法和放射免疫法对 98例 NIDDM患者 (其中并发高血压者 5 4例 )和 30例健康人血浆中 NO和 ET含量进行分析。结果 :NIDDM患者与健康人相比 ,患者血浆中 NO明显降低 ,NO血浆水平为 5 9.42μm ol/L (P<0 .0 5 ) ,ET明显增高 ,ET血浆水平为 80 .49ng/L (P<0 .0 1) ,并发高血压患者较不并发高血压患者这种变化更显著 ,二者差异有显著性 (P<0 .0 5 )。结论 :血浆中 NO和 ET含量变化在 NIDDM发病机理中可能起重要作用。
Objective: To investigate the changes of plasma nitric oxide (NO) and endothelin (ET) in patients with type 2 diabetes mellitus (NIDDM) and its clinical significance. Methods: The levels of NO and ET in 98 patients with NIDDM (54 with hypertension) and 30 healthy subjects were analyzed by nitrate reductase colorimetry and radioimmunoassay. Results: Compared with healthy controls, NIDDM patients had significantly lower plasma levels of NO, NO plasma levels of 5 9.42 μmol / L (P <0.05), ET significantly higher, and ET plasma levels of 80.49 ng / L P <0.01). This change was more significant in patients with hypertension than those without hypertension. The difference was significant (P <0.05). Conclusion: The changes of plasma NO and ET contents may play an important role in the pathogenesis of NIDDM.