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目的 :探讨玻璃体与青光眼眼压升高的关系。方法 :用玻璃体切割合并小梁切除治疗疑难青光眼及不同浓度的透明质酸酶注入兔眼玻璃体内改变玻璃体理化状态来降低眼压。结果 :玻璃体切割术后随访0 5～ 4年 ,患者眼压 80 %控制在正常范围 ,自觉症状消失 ,眼局部充血减轻或消失 ,视力多保持原来状态。用药 10～ 2 0～ 30d后 ,兔眼玻璃体粘稠度明显下降 ,眼压从 2 74kPa降至 1 73～ 1 33kPa。结论 :玻璃体切割合并小梁切除及透明质酸酶兔眼玻璃体内注射法均可使眼压下降 ,说明玻璃体对眼内压有一定的影响 ,但手术及实验结果和远期疗效均有待进一步研究。
Objective: To investigate the relationship between intraocular pressure (IOP) and glaucoma in vitreous. Methods: Vitreoretinal surgery combined with trabeculectomy for the treatment of intractable glaucoma and different concentrations of hyaluronidase into the vitreous of rabbit eyes to change the physical state of vitreous to reduce intraocular pressure. Results: After vitrectomy was followed up for 0 ~ 4 years, the intraocular pressure in 80% of patients was controlled within the normal range, and the symptoms disappeared. The local congestion was relieved or disappeared, and the visual acuity remained unchanged. After 10 ~ 20 ~ 30 d, the vitreous viscosity of rabbit eyes decreased obviously, and the intraocular pressure decreased from 2 74 kPa to 1 73 ~ 1 33 kPa. CONCLUSION: Intraocular pressure can be decreased by vitrectomy combined with trabeculectomy and intravitreal injection of hyaluronidase in rabbits, which shows that vitreous has some effect on intraocular pressure. However, the results of the operation and the long-term results need to be further studied .