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目的 :对比研究雪旺细胞标志物S10 0蛋白在腺样囊性癌及粘液表皮样癌中的表达 ,探讨其与腺样囊性癌嗜神经侵袭间的关系。方法 :选取 2 0例腺样囊性癌和 18例粘液表皮样癌标本 ,分别进行S10 0免疫组化染色。结果 :腺样囊性癌嗜神经侵袭的能力明显高于粘液表皮样癌 ,两者有显著性差异。S10 0在绝大多数腺样囊性癌中均有表达 ,而在粘液表皮样癌中则没有表达 ,两者有显著性差异。结论 :腺样囊性癌细胞发生了雪旺细胞分化进而侵袭神经可能是腺样囊性癌嗜神经侵袭的组织学基础
OBJECTIVE: To compare the expression of Schwann cell marker S10 0 in adenoid cystic carcinoma and mucoepidermoid carcinoma and to explore its relationship with the invasion of adenoid cystic carcinoma. Methods: Twenty cases of adenoid cystic carcinoma and 18 cases of mucoepidermoid carcinoma were selected for immunohistochemical staining of S10 0. Results: The ability of adenoid cystic carcinoma to attack nerves was significantly higher than that of mucoepidermoid carcinoma, with significant difference between the two. S10 0 was expressed in most adenoid cystic carcinomas, but not in mucoepidermoid carcinomas, both of which were significantly different. Conclusions: Schwann cell differentiation and invasion of adenoid cystic carcinoma may be the histological basis of adenoid cystic carcinoma