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目的探讨抗环瓜氨酸肽(CCP)抗体、类风湿因子(RF)、抗Sa抗体检测对类风湿关节炎的临床意义。方法对72例RA患者组,115例自身免疫性疾病组和102例正常对照组人群血清进行同时测定RF(速率散射比浊法)、抗CCP抗体(ELISA法)和抗Sa抗体(免疫印迹法),并对三者之间检测的一致性以及与其他临床指标的关系进行了分析。结果RF、抗CCP抗体和抗Sa抗体对RA的敏感性分别为83.3%、80.6%和33.3%,特异性分别为83.4%、97.2%和98.6%。三种指标两两联合检测对RA的诊断都具有较好的特异性,而敏感性以抗CCP抗体+RF最高(77.8%)。结论抗CCP抗体和抗Sa抗体均是RA特异性血清学指标,但两者与RF可相互补充,选择适当的指标联合检测有助于RA的早期诊断。
Objective To investigate the clinical significance of anti-cyclic citrullinated peptide (CCP) antibody, rheumatoid factor (RF) and anti-Sa antibody in rheumatoid arthritis. Methods Serum samples of 72 patients with RA, 115 patients with autoimmune diseases and 102 normal control subjects were measured simultaneously by RF (nephelometry), anti-CCP (anti-CCP) and anti-Sa ), And the consistency between the three tests and the relationship with other clinical indicators were analyzed. Results The sensitivity of RF, anti-CCP and anti-Sa antibodies to RA was 83.3%, 80.6% and 33.3%, respectively, and the specificity was 83.4%, 97.2% and 98.6% respectively. The combined detection of the three indexes has good specificity for the diagnosis of RA, while the sensitivity is the highest (77.8%) with the anti-CCP antibody + RF. Conclusions Both anti-CCP and anti-Sa antibodies are specific serological markers of RA. However, both of them can complement each other with RF. Selecting the appropriate combination of indices can be helpful for the early diagnosis of RA.