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苯并噻唑及其衍生物由于其独特的抗感染和抗肿瘤的特性,近年来引起广泛关注.本文报导了一种新的合成苯并噻唑类衍生物的方法:硫代苯甲酸乙酯与邻氨基疏基取代苯的缩合.这种方法操作简便,反应条件温和.尤其适合于底物有活泼官能团的情况.应用此方法,高收率合成了六个化合物.
Benzothiazole and its derivatives have drawn much attention in recent years due to their unique anti-infective and antitumor properties.In this paper, a new method for the synthesis of benzothiazole derivatives is reported: ethyl thiobenzoate and its adjacent Aminosulfonyl Substituted Benzene Condensation This method is simple to operate and has mild reaction conditions and is particularly suitable for the case where the substrate has a reactive functional group.In this method, six compounds were synthesized in good yields.