作者评价了低含量贯叶金丝桃素的贯叶金丝桃提取物对阿普唑仑、咖啡因、甲苯磺丁脲和地高辛等的药动学参数的影响。以往的研究表明,其他种类的贯叶金丝桃产品与上述药物合用时,由于前者引起细胞色素P450和p-糖蛋白(P-gp)活性增强,从而导致这些共服药物的血药浓度下降。在该项临 The authors evaluated the effect of Hypericum perforatum on the pharmacokinetic parameters of alprazolam, caffeine, tolbutamide, and digoxin. Previous studies have shown that when other types of St. John’s Wort products are used in combination with the above-mentioned drugs, the former results in increased activity of cytochrome P450 and p-glycoprotein (P-gp), resulting in a decrease in the plasma concentration of these co-administration drugs. In this item