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目的:探讨2型糖尿病合并糖尿病足患者与胰岛素抵抗的关系。方法:205例2型糖尿病患伴糖尿病足患者作为观察组,无足部病变的糖尿病患者作为对照组,观察其体重指数、空腹血糖、胰岛素、血脂等指标,两组间进行比较并相关性分析、多元回归分析。胰岛素抵抗指数(HOMA-IR)=FPG×FIns/22.5。结果:糖尿病足患者的HOMA-IR显著高于无糖尿病的患者(P<0.05)。多元回归分析显示糖尿病病程、LDL及BMI是影响2型糖尿病足患者胰岛素抵抗的主要危险因素。结论:糖尿病足患者存在着更严重的胰岛素抵抗。
Objective: To investigate the relationship between insulin resistance and type 2 diabetic patients with diabetic foot. Methods: Totally 205 diabetic patients with type 2 diabetes mellitus (T2DM) were selected as the observation group and diabetic patients without foot disease as the control group. Body mass index, fasting blood glucose, insulin, blood lipids and other indexes were observed and compared between the two groups ,Multiple regression analysis. Insulin Resistance Index (HOMA-IR) = FPG × FIns / 22.5. Results: HOMA-IR in patients with diabetic foot was significantly higher than those in patients without diabetes (P <0.05). Multiple regression analysis showed that duration of diabetes, LDL and BMI were the major risk factors of insulin resistance in patients with type 2 diabetic foot. Conclusion: Diabetic foot patients have more severe insulin resistance.