检测82例中老年人的α干扰素诱生能力,并以26例44岁以下的健康者为对照,其中5例并检测了血浆中的干扰素效价。结果:血浆中无论中老年人或对照者均未检出干扰素效价。45岁以上的中老年人干扰素诱生能力明显减低,可能为易患肿瘤及感染症的基础。肿瘤或(及)化疗病人以及严重感染的病人,干扰素诱生能力减低最明显,此时应用干扰素或其他增加干扰素诱生能力药物,可能有益。 The interferon-α induced ability of 82 middle-aged and elderly people was examined. Twenty-six healthy subjects under 44 years of age were taken as control. Five patients were tested for plasma interferon titer. RESULTS: Interferon titers were not detected in plasma in either middle-aged or elderly controls. Interferon induced ability of middle-aged and older people over the age of 45 obviously reduced, which may be the basis of susceptibility to cancer and infectious diseases. Patients with tumors or (and) chemotherapy and those with severe infections have the most pronounced reductions in interferon inducibility, and interferon or other drugs that increase interferon inducibility may be useful at this time.