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目的:探讨甲状腺功能与碘摄入的关系,指导临床合理用碘。方法:选取2014年5月~2015年5月就诊的480身材矮小患儿作为研究对象。按照甲状腺功能,将患儿分为三组:亚临床甲减组(SCH)、临床甲减组(CH)、甲状腺功能正常组。测试所有患儿的甲状腺功能、尿碘情况。结果:在1200例患儿中,有42例缺碘,占3.5%。有432例碘过量,占36%。有726例摄碘正常,占60.5%。其中,SCH 72例,占6%;CH 18例,占1.5%。正常组1116例,占93%。SCH组中,53例为高尿碘,占73.6%。与其他两组相比,SCH组高尿碘率更高,P<0.05,差异显著,具有统计学意义。对高尿碘患儿实施饮食控制、甲状腺素替代治疗后,尿碘恢复正常。结论:儿童摄入过量碘后,会导致亚临床甲减,应该定期为儿童进行常规尿碘检测,发现异常及时采取干预措施,避免影响儿童的身体、智力发育。
Objective: To investigate the relationship between thyroid function and iodine intake and to guide the rational use of iodine in clinical practice. Methods: 480 short stature children from May 2014 to May 2015 were selected as research objects. According to thyroid function, the children were divided into three groups: subclinical hypothyroidism group (SCH), clinical hypothyroidism group (CH), normal thyroid function group. Test all children with thyroid function, urinary iodine. Results: Of 1,200 children, 42 had iodine deficiency, accounting for 3.5%. There are 432 cases of iodine excess, accounting for 36%. There are 726 cases of normal iodine, accounting for 60.5%. Among them, SCH 72 cases, accounting for 6%; CH 18 cases, accounting for 1.5%. The normal group of 1116 cases, accounting for 93%. In SCH group, 53 cases were high urinary iodine, accounting for 73.6%. Compared with the other two groups, SCH group had higher urinary iodine rate, P <0.05, the difference was significant, with statistical significance. Dietary control of children with high urinary iodine, urinary iodine returned to normal after thyroid hormone replacement therapy. Conclusion: Children with excess iodine will lead to subclinical hypothyroidism. Regular urinary iodine testing should be performed on children regularly. Abnormalities should be detected timely and interventions should be taken to avoid affecting children’s physical and mental development.