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目的探讨双歧杆菌三联活菌胶囊联合标准三联疗法或四联疗法治疗幽门螺杆菌(Hp)感染性消化性溃疡的临床疗效。方法选取2012年7月—2014年7月木里县人民医院收治的137例Hp感染性消化性溃疡患者,随机分为标准三联组(45例,给予标准三联疗法)、双歧三联组(46例,给予双歧杆菌三联活菌胶囊+标准三联疗法)以及双歧四联组(46例,给予双歧杆菌三联活菌胶囊+四联疗法),比较3组的临床疗效、胃液p H值、Hp根治率、复发率及不良反应发生情况。结果治疗后3组胃液p H值、Hp根治率、临床疗效比较,差异有统计学意义(P<0.05);3组不良反应发生率、复发率比较,差异无统计学意义(P>0.05)。结论双歧杆菌三联活菌胶囊联合标准三联疗法或四联疗法治疗Hp感染性消化性溃疡疗效较好,不良反应少。
Objective To investigate the clinical efficacy of Bifidobacterium triple viable capsule combined with standard triple therapy or quadruple therapy in the treatment of H.pylori (Hp) -concerning peptic ulcer. Methods A total of 137 patients with Hp-infective peptic ulcer admitted to Muli County People’s Hospital from July 2012 to July 2014 were randomly divided into standard triple group (45 patients treated with standard triple therapy), bifunctional triple therapy group (46 Cases were given Bifidobacterium triple viable capsule + standard triple therapy) and bifunctional quadruple group (46 cases, given bifidobacterium triple viable capsule + quadruple therapy). The clinical efficacy, gastric p H value , Hp cure rate, recurrence rate and adverse reactions. Results There were significant differences in p H value, cure rate of Hp and clinical curative effect between the three groups after treatment (P <0.05). There was no significant difference in the incidence of relapse and recurrence among the three groups (P> 0.05) . Conclusion Bifidobacterium triple viable capsule combined with standard triple therapy or quadruple therapy Hp infection peptic ulcer effect is good, less adverse reactions.