目的:分析某军队医院药品不良反应(ADR)发生情况及规律和特点,为临床合理用药和推动ADR工作提供参考。方法:选择我院2013—2016年ADR报告2322例,从性别、年龄、引发ADR的药品种类、剂型、给药途径、ADR出现时间、ADR涉及的系统与器官、ADR程度分级、ADR转归,以及报告人等方面进行统计分析。结果:在2322例ADR报告中,男1221例,女1101例,男女比例为1.1:1,男性略高于女性。将ADR病例按照每10岁划分为8个年龄段,70岁以上的患者发生ADR的比例最高,为463例,占19.94%。在2322例ADR报告中,以抗微生物药引起的ADR最多,占21.27%;其次是抗肿瘤药,占16.71%;再次为心血管系统用药,占11.07%;在抗微生物药中,抗菌药物引起的ADR最多,为448例,占90.69%;在抗菌药物中,喹诺酮类最多,为:109例,占24.33%。给药途径中静脉滴注引起的ADR最多,为159例占68.60%;注射剂是引起的ADR次数最多的剂型,为1827例,占78.68%;用药后出现ADR的时间大多集中在30 min内,为892例,占38.41%。ADR累及的系统器官以胃肠系统为主,为656例,占24.65%。在2322例ADR报告中,按照新的严重、新的一般和严重、一般4级进行评价,新的严重ADR 10例(0.43%),新的一般176例(7.58%),严重200例(8.61%),一般1936例(83.38%)。2322例ADR报告中,单一用药的1681例(72.39%),联合用药641例(27.61%);自愈994例(42.81%),痊愈666例(28.68%),好转626例(26.96%),仍处于持续状态31例(1.34%)。在2322例ADR报告中,医师病例报告2279例(98.15%),护士报告40例(1.72%),药师报告3例(0.13%)。结论:我院ADR监测和上报工作得到加强,但护士、药师报告比例偏低,应采取相应措施。 Objective: To analyze the occurrence, regularity and characteristics of adverse drug reaction (ADR) in a military hospital and provide references for clinical rational use of medication and promotion of ADR. Methods: A total of 2322 cases of ADR from 2013 to 2016 in our hospital were selected according to gender, age, drug category, route of administration, ADR appearance time, ADR involved system and organ, ADR grade, ADR outcome, As well as reporters and other aspects of statistical analysis. Results: In 2322 ADR cases, there were 1221 males and 1101 females, with a male to female ratio of 1.1: 1. The male was slightly higher than the female. The ADR cases were divided into 8 age groups according to every 10 years. The incidence of ADR was the highest in patients over 70 years old, accounting for 19.94%. In the 2322 cases of ADR, anti-microbial drugs caused the most ADR, accounting for 21.27%; followed by anti-tumor drugs, accounting for 16.71%; once again for the cardiovascular system medication, accounting for 11.07%; antimicrobial drugs, antimicrobial drugs caused Of the ADR up to 448 cases, accounting for 90.69%; in the antibacterial drugs, quinolones up to: 109 cases, accounting for 24.33%. The most ADR was caused by intravenous drip, which accounted for 68.60% of 159 cases. Injections were the most frequently caused ADR dosage forms, 1827 cases, accounting for 78.68%. Most of ADR occurred after 30 minutes of treatment, 892 cases, accounting for 38.41%. ADR system organs mainly gastrointestinal system, 656 cases, accounting for 24.65%. In 2322 ADRs, 10 new patients with severe ADR (0.43%), 176 new patients (7.58%), and 200 serious patients (8.61%) were evaluated according to the new serious, new general and serious, %), Generally 1936 cases (83.38%). Among the 2322 ADR cases, 1681 (72.39%) were single-agent and 641 (27.61%) were combined. 994 cases (42.81%) recovered, 666 (28.68%) recovered and 626 Still in the continuous state of 31 cases (1.34%). Among 2322 ADR cases, 2279 cases (98.15%) were reported by physicians, 40 cases (1.72%) were reported by nurses and 3 cases (0.13%) by pharmacists. Conclusion: The monitoring and reporting of ADR in our hospital have been strengthened. However, the proportion of nurses and pharmacists reporting is low, and corresponding measures should be taken.