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目的:采用Meta分析方法评价黄芪注射剂治疗脑梗死的有效性及安全性.方法:计算机检索PubMed、Cochrane library、CNKI、SinoMed、VIP、万方数据、Embase数据库中有关黄芪注射剂治疗脑梗死的随机对照试验,检索时间限定为建库至2016年10月,2位研究者独立根据纳入与排除标准筛选文献,采用Cochrane风险评价表评价纳入文献的质量,提取资料并通过RevMan 5.3软件进行数据分析.结果:共纳入11篇文献,累计受试者1 031例,其中治疗组556例,对照组475例.Meta分析结果显示:在西医常规治疗的基础上,联用黄芪注射剂在提高治疗脑梗死的临床总有效率(RR=1.20,95％ CI:1.14 ～ 1.27,P＜0.000 01),降低脑梗死患者的全血高切黏度(MD=-0.65,95％CI:-1.24 ～-0.05,P=0.03)、全血低切黏度(MD=-0.87,95％ CI:-1.68 ～-0.07,P=0.03)、神经功能缺损程度(MD=-6.41,95％ CI:-8.06 ～-4.76,P＜0.000 01)等方面有更好疗效.4篇文献对不良反应/不良事件情况进行了报道,仅治疗组出现3例不良反应/不良事件.结论:临床治疗脑梗死的过程中,在西医常规治疗的基础上联合黄芪注射剂可以提高疗效,但因纳入文献数量较少,其方法学和研究质量较低,黄芪注射剂治疗脑梗死的临床疗效及安全性仍需大量严格、多中心、大样本的随机双盲对照试验来进行验证.“,”Objective:To evaluate systematically the clinical efficacy and safety of Huangqi injection in treatment of cerebral infarction.Methods:Two researchers searched and selected independently the randomized controlled trils (RCTs) regarding Huangqi injection in the treatment of cerebral infarction in CNKI,VIP,Wanfang Database,PubMed,the Cochrane library and so on by October 2016.Quality of included RCTs was evaluated by The Cochrane Risk of Bias Assessment Tool,and then the required information was extracted and meta-analyzed by RevMan 5.3 software.Results:A total of 11 RCTs involving 1 031 patients were included,556 cases in experiment group and 475 cases in control group.There were 662 male patients and 369 female patients.The result of meta-analyzed indicated that Huangqi injection group can achieve a better effect than the routine western medicine group in respect of total effective rate (RR =1.20,95％ CI:1.14-1.27,P ＜0.000 01).In addition,it could decrease the whole blood high shear viscosity (MD =-0.65,95％ CI:-1.24--0.05,P =0.03),whole blood low shear viscosity (MD =-0.87,95 ％ CI:-1.68--0.07,P =0.03),and achieve a better effect in the degree of neurological impairment (MD =-6.41,95％ CI:-8.06--4.76,P ＜ 0.000 01).3 articles cleared that there was no ADRs in the studies,1 study reported 3 cases of ADRs.ADRs were all in the experimental group,but there were no serious happened adverse effects.Conclusion:Huangqi injection is effective in treating cerebral infarction.However,these results should be carefully interpreted due to the low methodology quality and small sample size of trials,the evidence of Huangqi injection for treating cerebral infarction requires large-scale and double-blind RCTs to substantiate these findings.