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目的：观察川芎嗪注射液对家兔肝缺血再灌注损伤（ＨＩＲＩ）的保护作用。方法：制备家兔ＨＩＲＩ模型，３０只健康家兔随机分为３组：假手术组１０只，损伤组１０只，川芎嗪保护组１０只。观察肝组织及血中超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨＰｘ）活性、丙二醛（ＭＤＡ）含量及肝细胞形态学变化。结果：肝缺血再灌注后，川芎嗪保护组与损伤组比较，血浆中ＳＯＤ明显升高〔缺血４５分钟，损伤组（２５１．００±３１．００）ｋＵ／Ｌ，川芎嗪保护组（３４１．００±２４．００）ｋＵ／Ｌ，Ｐ＜０．０１；再灌注４５分钟，损伤组（１７１．００±２２．００）ｋＵ／Ｌ，川芎嗪保护组（３３１．００±４２．００）ｋＵ／Ｌ，Ｐ＜０．０１〕；ＭＤＡ下降非常显著〔再灌注４５分钟，损伤组（７．７０±０．６６）μｍｏｌ／Ｌ，川芎嗪保护组（６．１０±０．６４）μｍｏｌ／Ｌ，Ｐ＜０．０１〕；肝组织中ＳＯＤ、ＧＳＨＰｘ均明显升高〔ＳＯＤ损伤组（４７７．００±８９．００）ｋＵ／ｇ，川芎嗪保护组（７０４．００±４５．００）ｋＵ／ｇ，Ｐ＜０．０１；ＧＳＨＰｘ损伤组（２４．２０±３．７０）ｋＵ／ｇ，川芎嗪保护组（３３．１０±４．８０）ｋＵ／ｇ，Ｐ＜０．０１〕，且伴?
Objective: To observe the protective effect of ligustrazine injection on hepatic ischemia-reperfusion injury (HIRI) in rabbits. Methods: Rabbit HIRI model was prepared. Thirty healthy rabbits were randomly divided into three groups: sham operation group (n = 10), injury group (n = 10) and ligustrazine protection group (n = 10). The activities of SOD, GSHPx, malondialdehyde (MDA) and the morphological changes of hepatocytes in liver tissue and blood were observed. Results: Compared with injured group, the protective effect of ligustrazine in the protective group was significantly higher than that in the injured group [ischemia 45 minutes, injury group 251.0 ± 31.00 kU / L, ligustrazine protection group ( 341.00 ± 24.00) kU / L, P <0.01; 45 minutes after reperfusion, the injury group (171.00 ± 22.00) kU / L, ligustrazine protection group ) KU / L, P <0.01]; MDA decreased very significantly (45 min after reperfusion, 7.70 ± 0.66 μmol / L in injury group and 6.10 ± 0.64 in ligustrazine group) μmol / L, P <0.01〕. The levels of SOD and GSHPx in liver tissue were significantly increased 〔477.00 ± 89.00〕 kU / g in SOD group and 704.00 ± 45.00 in tetramethylpyrazine group ) KU / g, P <0.01; GSHPx injury group (24.20 ± 3.70) kU / g, ligustrazine protection group (33.10 ± 4.80) kU / g, P <0.01〕, and with?