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血液学家熟知在光镜下检查 Romanow-sky 染色的血涂片时,在人和动物某些淋巴细胞胞质内,可清楚地看到被天青染料染色的小颗粒——嗜天青颗粒(AG)。近年来,含天青颗粒的淋巴细胞的功能已被确认下来。用密度梯度分层离心法,从人血液中分离出高纯度的天然杀伤细胞(NK),发现其中绝大部分为含AG 的大淋巴细胞。这种细胞便称为大颗粒淋巴细胞(LGL)。“颗粒淋巴细胞”一词欠妥。已在人、大鼠和小鼠查到 LGL。本综述专门论述人 LGL 的特点。1.LGL、NK 细胞和 TG 淋巴细胞的相互关系:业已证明,NK 细胞是一种效应细
Hematologists are well aware of Romanow-sky-stained blood smears under light microscopy and are clearly visible in the cytoplasm of some lymphocytes of humans and animals - azurophilic granules (AG). In recent years, the function of lymphocytes containing azure granules has been confirmed. High-purity natural killer cells (NK) were isolated from human blood by density gradient centrifugation and found to be predominantly AG-containing macrophages. This kind of cell is called large granular lymphocyte (LGL). The term “granulocyte” is defective. LGL has been found in humans, rats and mice. This review focuses on the characteristics of people LGL. 1. Interrelationship between LGL, NK Cells and TG Lymphocytes: It has been shown that NK cells are an effector