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目的:随机观察恩丹西酮与胃复安并小剂量地塞米松控制大剂量顺铂为主的化疗所致的迟缓呕吐。方法:79例经组织学或细胞学检查确诊为肺癌或乳腺癌者,接受大剂量顺铂(90～100mg/m2))为主的联合化疗。随机分为两组,A组37例于顺铂后8小时开始口服恩丹西酮(8mg,q8h,dl～3),B组42例于顺铂后8小时开始口服胃复安(20mg,q8h,dl～3)并地塞米松(l.5mg,q8h,dl～3)。结果:A组控制迟缓呕吐完全缓解率(CR)为29.7%,基本控制率(CR+PR)为70.3%。B组各为52.4%和88.1%,两组比较均有显著差异(P<0.05)。结论:顺铂后d2～6口服胃复安及地塞米松控制迟缓呕吐疗效优于口服恩丹西酮。
Objective: Random observation of ondansetron and metoclopramide and low-dose dexamethasone control high-dose cisplatin-based chemotherapy-induced delayed vomiting. METHODS: Seventy-nine patients diagnosed with lung cancer or breast cancer by histology or cytology were treated with high-dose cisplatin (90-100 mg / m2). Randomly divided into two groups, 37 patients in group A started oral oral ondansetron (8mg, q8h, dl ~ 3) 8 hours after cisplatin, 42 patients in group B started oral metoclopramide 8 hours after cisplatin (20mg, q8h, dl ~ 3) and dexamethasone (l.5mg, q8h, dl ~ 3). Results: The complete remission rate (CR) of group A was 29.7% and the rate of basic control (CR + PR) was 70.3%. B group were 52.4% and 88.1% respectively, there was significant difference between the two groups (P <0.05). Conclusion: The effect of d2 ~ 6 oral metoclopramide and dexamethasone on delayed vomiting after cisplatin is better than oral ondansetron.