论文部分内容阅读
氟氯青霉素对青霉素耐药葡萄球菌等有很强的灭菌活性,自1976年上市后得到广泛应用。最近瑞典药品有害委员会(SADRAC)报告了该药的毒副作用,其中约31%为对肝脏的损害,主要表现为胆汁瘀滞并伴有黄疸、胆红素上升(最高达429μm/L),停药后数月内可恢复,但有的患者停药四年后仍达100μm/L以上。有的患者为“无症状”性黄疸,有的右侧腹痛、发热、发疹。一名患者因迟发性出血死亡。检查发现肝小管损害、肝外闭塞、门脉炎症。该委员会报告指出,鉴于氟氯青霉素有较严重的肝损害,应用时要注意适应症,最好仅限用于对耐青霉素葡萄球
Flucloxacillin penicillin-resistant Staphylococcus aureus has a strong sterilization activity, since 1976 after the market has been widely used. Recently, the Swedish Drug Hazard Committee (SADRAC) reported the toxic side effects of the drug, of which about 31% were liver damage, mainly bile stasis with jaundice, elevated bilirubin (up to 429μm / L), stop Within a few months after the resumption of medicine, but some patients still up to four years after the withdrawal of more than 100μm / L. Some patients with “asymptomatic” jaundice, and some right abdominal pain, fever, rash. One patient died of delayed bleeding. Check found damage to the liver tubules, extrahepatic occlusion, portal inflammation. The commission’s report states that, given the more severe liver damage caused by fluconicillin, attention should be paid to indications for use, preferably only for penicillin-resistant grafts