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溶瘤病毒是一类具有复制能力的肿瘤杀伤型病毒。这类病毒可以依靠病毒本身的特异性在肿瘤细胞中复制而杀死并裂解肿瘤细胞,从中释放出来的病毒又可以进一步感染周围的肿瘤细胞,以此达到理想的治疗效果。腺病毒和人类Ⅰ型疱疹病毒是目前治疗胰腺癌研究最深入的溶瘤病毒。使用溶瘤病毒治疗胰腺癌的优点在于并不是每一个细胞都需要病毒转染,并且正常组织细胞不会受到影响,因而具有非常广阔的应用前景。现对溶瘤病毒治疗胰腺癌的作用机制进行综述。
Oncolytic viruses are a type of replication-competent tumor-killing virus. These viruses can rely on the virus’s own specificity to replicate in tumor cells to kill and lyse tumor cells, the virus released from it can further infect the surrounding tumor cells, so as to achieve the desired therapeutic effect. Adenoviruses and human herpesvirus type 1 are currently the most studied oncolytic viruses for the treatment of pancreatic cancer. The advantage of using oncolytic virus in the treatment of pancreatic cancer is that not every cell needs virus transfection, and normal tissue cells will not be affected, so it has a very broad application prospect. Now oncolytic virus treatment of pancreatic cancer mechanisms are reviewed.