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设计合成了１０个未见文献报道的２－对甲氧基苯亚甲基－５－取代胺甲基环戊酮衍生物，均经红外光谱、核磁共振谱及元素分析证实其化学结构．采用角叉菜胶诱发的大鼠足爪肿胀模型对抗炎活性进行了初步筛选．在化学合成中证实：Ｍａｎｎｉｃｈ碱的胺交换反应是消除加成反应
Ten novel 2-p-methoxybenzylidene-5-substituted aminomethylcyclopentanone derivatives were reported. Their chemical structures were confirmed by IR, 1H NMR and elemental analysis. Anti-inflammatory activity was initially screened using carrageenan-induced rat paw swelling model. In chemical synthesis confirmed: Mannich alkali amine exchange reaction is to eliminate the addition reaction