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用ＥＬＩＳＡ方法对７８例肾小球疾病患儿做尿视黄醇结合蛋白（ＲＢＰ），β＿２一微球蛋白（β＿２一ＭＧ）及Ｎ一乙酰一β一Ｄ一氨基葡萄糖苷酶（ＮＡＧ）检测，并与８５例健康儿童相比较。结果发现：肾小球疾病组尿ＲＢＰ值急性期显著高于对照组（Ｐ＜０．０１）；缓解期与对照组结果相接近（Ｐ＞０．０５）．说明原发性肾小球疾病患儿确有不同程度肾小管功能受损；尿ＲＢＰ值的改变不仅能反映肾小管功能受损程度及反映病情转归，而且比β＿２一ＭＧ，ＮＡＧ更敏感。
78 patients with glomerular disease were tested for urinary retinol binding protein (RBP), β_2-microglobulin (β_2-MG) and N-acetyl-β-D-glucosaminidase (NAG) , Compared with 85 healthy children. The results showed that the urinary RBP value in glomerular disease group was significantly higher than that in control group (P <0.01). The remission period was similar to that in control group (P> 0.05). This shows that children with primary glomerular disease indeed have different degrees of renal tubular dysfunction; changes in RBP value of urine not only reflect the extent of renal tubular dysfunction and reflect the outcome of the disease, but also more sensitive than β_2 MG, NAG.