目的：研究大鼠脑缺血再灌流体感诱发电位（ＳＥＰ）变化。方法：建立脑缺血再灌流动物模型，随机分成正常对照组９只，缺血和再灌流组２９只，在缺血１ｈ、２ｈ和再灌流１ｈ分别进行神经功能缺损评分，于缺血２ｈ再灌流１ｈ进行ＳＥＰ观察。结果：大鼠脑缺血时，神经功能缺损以轻、中度局灶性损害为主要表现，再灌流后变化不明显，只有１只体征加重。ＳＥＰ检测缺血、再灌流组与正常对照组比较，Ｐ１、Ｎ１峰值潜伏期延长，Ｐ１Ｎ１峰峰波幅降低（Ｐ＜００１），缺血组与再灌流组比较，Ｐ１、Ｎ１峰值潜伏期、Ｐ１Ｎ１峰峰波幅没有显著差异（Ｐ＞００５）。结论：ＳＥＰ是研究大鼠脑缺血再灌流有效可靠的手段，它能较早反映脑缺血及大脑神经功能的改变，客观反映再灌流后神经功能有无恢复的情况 Objective: To study the changes of somatosensory evoked potential (SEP) after cerebral ischemia-reperfusion in rats. Methods: The animal model of cerebral ischemia / reperfusion was established and randomly divided into normal control group (n = 9) and ischemia and reperfusion group (n = 29). Neurological deficit score was observed at 1h, 2h and 1h after reperfusion. Perfusion 1h SEP observation. Results: During the cerebral ischemia in rats, the neurological deficits were mainly manifested as mild or moderate focal lesion. After reperfusion, there was no obvious change, and only one symptom was aggravated. Compared with the control group, the peak latency of P1 and N1 and the peak amplitude of P1N1 decreased (P <001). Compared with the ischemia reperfusion group, the peak latency of P1 and N1 , P1N1 peak amplitude was not significantly different (P> 0  05). Conclusion: SEP is an effective and reliable method to study cerebral ischemia-reperfusion in rats. It can reflect the changes of cerebral ischemia and brain function earlier, objectively reflect the recovery of nerve function after reperfusion