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目的:探讨血清P选择素(P-selectin)和组织因子(TF)的表达在肺血栓栓塞症(PTE)的意义。方法:选择PTE患者158例(PTE组)和健康对照者142例(健康对照组),采用酶联免疫法(ELISA)测定两组空腹血清P-选择素和TF表达水平并进行比较;同时检测空腹血糖、血脂、血常规、纤维蛋白原、D-二聚体等指标,并进行相关分析。结果:与健康对照组相比,PTE组P-选择素[(11.62±2.82)μg/L∶(16.31±1.25)μg/L]、TF[(21.32±6.33)ng/L∶(24.15±5.01)ng/L]表达水平较对照组明显升高(P<0.01)。大面积和次大面积PTE患者(A组)P选择素[(17.30±1.15)μg/L∶(15.85±2.10)μg/L]和TF[(26.71±5.51)ng/L∶(23.12±3.86)ng/L]表达水平明显高于非大面积患者(B组,P<0.05)。PTE组P选择素与白细胞计数、血小板计数、纤维蛋白原、空腹血糖、总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)呈正相关(r=0.181~0.333,P<0.05);TF与白细胞计数、血小板计数、纤维蛋白原、空腹血糖和HDL-C呈正相关(r=0.216~0.384,P<0.05),P选择素与TF呈正相关(r=0.244,P<0.05)。结论:肺血栓栓塞症患者P选择素和组织因子水平显著升高,二者与肺血栓栓塞症病情密切相关,共同参与了肺栓塞的炎症反应和血栓形成过程。
Objective: To investigate the significance of serum P-selectin and tissue factor (TF) expression in pulmonary thromboembolism (PTE). Methods: 158 PTE patients (PTE group) and 142 healthy controls (healthy control group) were selected. The fasting serum P-selectin and TF expression levels were determined by enzyme-linked immunosorbent assay (ELISA) Fasting blood glucose, blood lipids, blood, fibrinogen, D-dimer and other indicators, and correlation analysis. RESULTS: Compared with healthy controls, the PTE levels in PTE group (P <0.01) ) ng / L] was significantly higher than that of the control group (P <0.01). P selectin [(17.30 ± 1.15) μg / L: (15.85 ± 2.10) μg / L] and TF [(26.71 ± 5.51) ng / L: (23.12 ± 3.86) in large area and large area PTE patients (group A) ) ng / L] was significantly higher than that in non-large-area patients (group B, P <0.05). PTE was positively correlated with white blood cell count, platelet count, fibrinogen, fasting blood glucose, total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) in PTE group (r = 0.181-0.333, P <0.05) There was a positive correlation between P-selectin and TF (r = 0.244, P <0.05), and white blood cell count, platelet count, fibrinogen, fasting blood glucose and HDL-C were positively correlated with each other (r = 0.216-0.384, P <0.05). CONCLUSION: The levels of P-selectin and tissue factor in patients with pulmonary thromboembolism are significantly increased. Both of them are closely related to the pulmonary thromboembolism and participate in the inflammatory reaction and thrombosis of pulmonary embolism.