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目的:进一步研究异丙酚在脊髓水平的作用并探讨异丙酚对脊髓外周伤害性和非伤害性传入刺激传递的抑制作用是否有所不同。方法:以肌电描记和脊髓背角神经元细胞外记录为方法,观察静脉给予2.0mg/kg异丙酚对断脊髓大鼠肌电C反应和背角广动力范围(WDR)神经元放电的影响。结果:异丙酚能够显著地抑制肌电C反应、及WDR神经元的早串放电、晚串放电和自发放电。与早串放电相比,异丙酚对晚串放电的抑制强度相对较高,而抑制时间相对较短。结论:异丙酚对脊髓外周伤害性和非伤害性传入刺激的传递都有抑制作用,与非伤害性传入刺激的传递相比,异丙酚对伤害性传入刺激的抑制强度较高,而抑制时间相对较短。
OBJECTIVE: To further investigate the role of propofol at the spinal level and to investigate whether propofol inhibits the suppressive effects of nociceptive and noninvasive afferent stimulation on the periphery of the spinal cord. Methods: Electromyography and extracellular recording of neurons in dorsal horn were used to observe the effects of intravenous propofol (2.0 mg / kg) on myoelectric C reaction and discharge of dorsal horn wide dynamic range (WDR) neurons influences. RESULTS: Propofol significantly inhibited myoelectrical C-response, early discharge of WDR neurons, late discharge and spontaneous discharge. Compared with the early string discharge, the inhibitory effect of propofol on the late string discharge is relatively high and the inhibition time is relatively short. CONCLUSIONS: Propofol inhibits the transmission of both nociceptive and non-nociceptive afferent stimuli in the peripheral spinal cord. Compared with the delivery of noninvasive afferent stimuli, propofol has a greater inhibitory effect on noxious afferent stimuli , While the inhibition time is relatively short.