胃食管反流性疾病(gastroesophageal reflux dis-ease,GERD)是指胃十二指肠内容物反流入食管引起烧心等症状的疾病,可引起反流性食管炎(refluxesophagitis,RE),以及咽喉、气道等食管邻近的组织损害[1]。Halstead[2]发现,GERD可引起食管反流性咽喉炎,引起顽固性咳嗽、咽喉不适、声嘶等症状,质子泵抑制剂及胃肠动力药能够显著改善症状。我们于 Gastroesophageal reflux dis-ease (GERD) is a disease in which gastroduodenal reflux into the esophagus can cause heartburn and other symptoms. It can cause refluxesophagitis (RE), as well as throat, Airways and other esophageal tissue damage [1]. Halstead [2] found that GERD can cause esophageal reflux disease, causing stubborn cough, throat discomfort, hoarseness and other symptoms, proton pump inhibitors and gastrointestinal motility drugs can significantly improve the symptoms. We are here