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本文介绍Na~+与高血压病和Ca~(2+)与血管平滑肌收缩的关系,以及Na~+-Ca~(2+)交换在维持细胞内Ca~()2+浓度和最终对血管平滑肌张力的影响,并介绍了噻嗪类药物治疗高血压病可能的作用机制。
This article describes the Na ~ + and hypertension and Ca ~ (2+) and vascular smooth muscle contraction, and Na ~ + -Ca ~ (2+) exchange in the maintenance of intracellular Ca ~ (2+) concentration and ultimately on the blood vessels Smooth muscle tension, and describes the possible mechanism of action of thiazide in the treatment of hypertension.