目的　探讨建立一种理想的大鼠肝硬化模型的复制方法。方法　 80只雄性 SD大鼠随机分为两组 ,实验组 (4 0只 )诱导期间四氯化碳浓度在一定范围内逐步增加 ,并用食用白酒替代医用乙醇溶液 ;对照组 (4 0只 )用传统的诱导方法进行诱导。观察两组大鼠在经四氯化碳等处理后的死亡率和肝脏假小叶的形成率。结果　实验组 4 0只 SD大鼠肝硬化模型诱导 9周共死亡 3只 ,死亡率 7.5 % ;对照组死亡率 1 7.5 % (P<0 .0 5 )。实验组 36只大鼠观察到肝硬化结节形成及镜下假小叶形成 ,假小叶的形成率为 90 .0 % ;对照组假小叶的形成率为 75 .0 % (P<0 .0 5 )。结论　适度提高四氯化碳的浓度并采用食用白酒替代医用乙醇溶液诱导大鼠肝硬化模型死亡率低 ,成功率高 Objective To explore an ideal method for replicating rat liver cirrhosis model. Methods Eighty male Sprague-Dawley rats were randomly divided into two groups. The experimental group (40 rats) gradually increased carbon tetrachloride (CTC) concentration within a certain range during the induction period, and the alcoholic liquor was used instead of the medical ethanol solution. The control group (40 rats) Traditional induction method for induction. The mortality and hepatic pseudolobule formation rate of the two groups of rats after treatment with carbon tetrachloride and the like were observed. Results In the experiment group, 40 rats were randomly divided into three groups, and the mortality rate was 7.5%. The mortality rate in the control group was 7.5% (P <0.05). 36 rats in the experimental group were observed cirrhosis and nodular pseudolobule formation, the formation rate of false lobule was 90.0%; the control group, false lobule formation rate was 75.0% (P0.05 ). Conclusion The moderate increase of carbon tetrachloride concentration and the use of edible liquor instead of medical ethanol solution induced liver cirrhosis model with low mortality and high success rate