新生儿缺血缺氧性脑病(hypoxic-ischemic en-cephalopathy,HIE)是新生儿在生后短期内诊断出的由于脑内供血供氧不足导致的缺氧缺血性脑损伤。在发达国家,HIE在足月儿中的发病率约为1.5/1000[1],其中15%~20%在新生儿期死亡,存活者25%~30%可能留有远期神经发育后遗症,严重威胁新生儿的生命及健康,给家庭和社会造成巨大的负担[2]。近来多中心试验[3]及Meta分析[4]表明低温疗 Hypoxic-ischemic encephalopathy (HIE) is a neonatal hypoxic-ischemic brain injury caused by insufficient oxygen supply to the brain in a short time after birth. In developed countries, the incidence of HIE in term infants is about 1.5 / 1000 [1], 15% to 20% of them die in the neonatal period, 25% to 30% of survivors may have long-term neurological sequelae, Serious threat to the life and health of newborns, to the family and society a huge burden [2]. Recent multicenter trials3 and meta-analysis4 have shown hypothermia