目的:探讨重症医学科医院感染的管理与控制措施。方法:选取2014年重症医学科收治的100例患者的临床资料进行回顾性分析,分析引起医院感染的高危因素;选择2015年重症医学科实施对症管理干预措施的100例患者进行比较,观察干预前后医院感染率的情况。结果:年龄、住院时间、侵入性操作、长期服用抗生素和大量使用激素是导致ICU患者发生医院感染的高危因素(P<0.05)。干预前有13例患者发生医院感染,感染率13.00%;干预后仅3例患者发生医院感染,感染率3.00%(P<0.05)。结果:针对ICU患者发生医院感染的高危因素给予对症干预,能够有效降低ICU患者的医院感染率,提高ICU患者的生活质量。 Objective: To discuss the management and control of Nosocomial Infection in Critical Care Medicine. Methods: The clinical data of 100 patients admitted to the Department of Critical Care Medicine in 2014 were retrospectively analyzed to analyze the risk factors of nosocomial infection. The 100 patients who were selected for the symptomatic management intervention in the Department of Critical Care Medicine in 2015 were compared. Before and after the intervention Hospital infection rate. Results: Age, length of hospital stay, invasive procedures, long-term use of antibiotics and intensive use of hormones were the most frequent risk factors for nosocomial infections in ICU patients (P <0.05). Thirteen patients had nosocomial infection before the intervention, with an infection rate of 13.00%. Only 3 patients developed nosocomial infection after the intervention, with an infection rate of 3.00% (P <0.05). Results: According to the high risk factors of nosocomial infection in ICU patients, symptomatic intervention was given to reduce the nosocomial infection rate in ICU patients and improve the quality of life in ICU patients.