论文部分内容阅读
目的 探讨结肠慢传输型便秘(STC)患者结肠动力和血液中胃动素(MLT)、生长抑素(SS)、神经降压素(NT)之间的关系。方法 运用结肠运输试验判断STC患者结肠动力。采用放免法测定空腹及餐后 1h血中MLT、NT、SS的浓度水平,与结肠运输试验的标记物排空率作相关性分析。结果 STC患者的空腹和餐后胃肠激素含量分别为: (1)MLT227 92±90 46pg/ml、267 94±126 68pg/ml,餐后 1h的水平低于正常组的 336 16±116 06pg/ml(P<0 05)。(2)SS43 13±33 70pg/ml、25 88±11 51pg/ml,空腹血浆SS水平高于正常组的 18 52±14 88pg/ml(P<0 01)。(3)NT78 75±52 88pg/ml、110 25±97 08pg/ml,空腹血浆NT水平高于正常组的46 95±18 12pg/ml(P<0 05)。STC患者结肠排空率与餐后血浆MLT含量呈正相关,与空腹SS水平呈负相关。结论 本研究表明,STC患者血液中特定的胃肠激素水平异常可能与结肠运输障碍有关。
Objective To investigate the relationship between colonic motility and motilin, somatostatin (SS) and neurotensin (NT) in colonic slow transit constipation (STC). Methods The colonic transport test was used to determine the colonic motility in STC patients. The levels of MLT, NT and SS in the fasting and 1h postprandial blood were determined by radioimmunoassay, and correlated with the marker evacuation rate of colon transport test. Results The fasting and postprandial gut hormones in STC patients were (1) MLT227 92 ± 90 46pg / ml and 267 94 ± 126 68pg / ml, respectively. The levels of fasting and postprandial 1h after meal were lower than those of the normal group (336 16 ± 116 06pg / ml (P <0 05). (2) SS43 13 ± 33 70 pg / ml, 25 88 ± 11 51 pg / ml, fasting plasma SS level was 18 52 ± 14 88 pg / ml (P <0.01) of the normal group. (3) NT78 75 ± 52 88 pg / ml, 110 25 ± 97 08 pg / ml, fasting plasma NT level was 46 95 ± 18 12 pg / ml (P <0.05) of the normal group. There was a positive correlation between colon emptying rate and postprandial plasma MLT levels in STC patients and a negative correlation with fasting SS levels. Conclusion This study shows that abnormal blood levels of specific gastrointestinal hormones in STC patients may be related to colonic transport disorders.