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目的对腋淋巴结阴性乳腺癌患者进行预后分析。方法选择２２个可能对腋淋巴结阴性乳腺癌患者预后产生影响的非重复特征性临床因素，通过计算机Ｃｏｘ多因素分析模型，利用累积生存率，对１４８４例手术切除的腋淋巴结阴性乳腺癌患者进行预后分析。结果在选取的２２个因素中，月经状况、妊娠次数、病期、合并妊娠或哺乳、肿瘤大小、内乳淋巴结、术后放疗、术后三苯氧胺辅助治疗是影响腋淋巴结阴性乳腺癌患者预后的独立预后因素（Ｐ＜０．０５）。结论用临床资料对腋淋巴结阴性乳腺癌患者进行预后分析，可发现部分高危人群。腋淋巴结阴性的乳腺癌患者术后不宜放疗或行卵巢切除，术后三苯氧胺辅助治疗不应仅局限于绝经后或雌激素受体阳性的患者。如何选择高危人群进行术后化疗，有待进一步研究。
Objective To analyze the prognosis of axillary lymph node negative breast cancer patients. Methods Twenty-two non-repeated clinical factors that may influence the prognosis of patients with axillary lymph node-negative breast cancer were selected. The cumulative survival rate of 1484 patients with axillary lymph node-negative breast cancer who underwent surgical resection was calculated by computer Cox multivariate analysis model. analysis. Results Of the 22 factors selected, menstrual status, number of pregnancies, stage of disease, combined pregnancy or breastfeeding, tumor size, internal breast lymph node, postoperative radiotherapy, and postoperative tamoxifen adjuvant therapy were independent predictors of prognosis in patients with axillary lymph node-negative breast cancer. Prognostic factors (P < 0.05). Conclusions Prognosis analysis of patients with axillary lymph node-negative breast cancer using clinical data can reveal some high-risk groups. Axillary lymph node-negative breast cancer patients should not undergo radiotherapy or oophorectomy after surgery. Postoperative tamoxifen adjuvant therapy should not be limited to postmenopausal or estrogen receptor-positive patients. How to choose high-risk groups for postoperative chemotherapy remains to be further studied.