目的：评价甘氨双唑钠的一般生殖毒性。方法：采用Ⅰ段生殖毒性试验。设０，３３．３，１００．０和３００．０ｍｇ／ｋｇ４个组。雄性ＩＣＲ小鼠交配前经腹腔注射连续给药６０ｄ，雌性小鼠交配前经皮下注射连续给药１４ｄ，然后继续给药至哺乳期结束。结果：各剂量组给药期间对雄性小鼠体质量增长有不同程度的影响，其中高剂量组与对照组比较差异有统计学意义；中、高剂量组睾丸质量增加；各剂量组附睾精子数均降低，精子活动度也有不同程度的下降，但对生育率无明显影响，睾丸组织也未见明显的病理改变。结论：在受试剂量下，该药对雄鼠有一定的生殖毒性，但对生育率和雌鼠生殖功能以及子代无明显影响 Objective: To evaluate the general reproductive toxicity of glycididazole sodium. Method: The reproductive toxicity test of stage Ⅰ was adopted. Three groups of 0, 33.3, 100.0 and 300.0 mg / kg were set. Male ICR mice were injected intraperitoneally for 60 days before mating. Female mice were administered subcutaneously for 14 days prior to mating and then continued until the end of lactation. Results: The growth of male mice in each dose group had different effects on the growth of body weight. The high dose group had significant difference compared with the control group; the testis mass of middle and high dose groups increased; the number of sperm in each dose group Were decreased, sperm motility decreased to varying degrees, but no significant effect on fertility, testicular tissue showed no significant pathological changes. Conclusion: The drug has certain reproductive toxicity to males at the doses tested, but has no significant effect on fertility and female reproductive function and offspring