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行为实验己经证明，锌过多或缺锌均可影响脑功能。锌作为体内重要的微量元素，影响多种酶的活性及蛋白质和核酸的台成。本实验通过体外分离大鼠脑海马突触体，观察不同浓度锌离子对Ca2+－Mg2+ATP酶的活性和3H－Leu掺入突触蛋白合成的影响．结果表明：1．锌离子浓度在25μmol／L时增加该酶的活性（＜0．01），并促进3H－Leur掺入蛋白质的合成（＜0．05）。2．锌离子在50,100，200μmol／L的较高浓度时对Co2+－M2+ATP酶的活性有显著的抑制作用（分别为：P＜0.05．P＜0．01，P＜0.01），仅200μmol／L对3H—Leu掺入突触蛋白合成有抑制作用。本研究提示：适量的锌对突触体功能的维持是必要的，但剂量过高则起相反作用。
Behavioral experiments have shown that excessive zinc or zinc deficiency can affect brain function. Zinc, as an important trace element in the body, affects the activity of many enzymes and the synthesis of proteins and nucleic acids. In this study, hippocampal synaptosomes were isolated from rat hippocampus in vitro and the effects of different concentrations of zinc ions on the activity of Ca2 + -Mg2 + ATPase and 3H-Leu incorporation into synaptic proteins were observed. The result shows: 1. The zinc ion concentration at 25μmol / L increased the enzyme activity (<0.01) and promoted the incorporation of 3H-Leur protein (<0.05). 2. Zinc ions significantly inhibited the activity of Co2 + -M2 + ATPase (P <0.05, P <0.01, P <0.01, respectively) at higher concentrations of 50, 100 and 200 μmol / 3H-Leu incorporation synaptic protein synthesis inhibition. This study suggests that: the amount of zinc on the maintenance of synaptic function is necessary, but the dose is too high has the opposite effect.