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目的:采用Box-Behnken法设计优化新血宝分散片的处方。方法:考察微晶纤维素、低取代羟丙纤维素、交联聚维酮、胶态二氧化硅等辅料对新血宝分散片质量的影响。结果:处方Ⅲ制备的新血宝分散片符合英国药典中分散片的标准。结论:处方Ⅲ适合制备新血宝分散片。
OBJECTIVE: To design and optimize the prescription of XinBaoBao dispersible tablets by Box-Behnken method. Methods: The effects of microcrystalline cellulose, low-substituted hydroxypropyl cellulose, crospovidone, colloidal silica and other excipients on the quality of Xinbubao dispersible tablets were investigated. Results: The new blood-dispersible tablet prepared by prescription Ⅲ conformed to the standard of dispersible tablet in British Pharmacopoeia. Conclusion: Formulation Ⅲ is suitable for preparation of Xinbubao Dispersible Tablets.