【摘 要】
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The present study was designed to determine the chemical constituents of the stem tuber ofPinellia pedatisecta.The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of
【机 构】
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School of Chemical Engineering, Institute of Pharmaceutical Engineering Technology and Application,
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The present study was designed to determine the chemical constituents of the stem tuber ofPinellia pedatisecta.The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physieochemical properties and spectral data.Three new alkaloids (compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9H-purin-6-amine (1), 4-(2-(2, 5-dioxopyrrolidin-l-yl)ethyl)phenyl acetate (2), and N-(9-((5-methoxypyridin-2-yl)methyl)-9H-purin-6-yl)acetamide (3).These compounds were evaluated for their cytotoxicity against human cervical cancer HeLa cells.Compounds 1 and 3 significantly inhibited the proliferation of HeLa cells with IC50 values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L-1, respectively.
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