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目的探讨儿童活体肝移植术后常见细菌感染种类及药物敏感性。方法对我院2006年6月至2009年3月共22例活体肝移植患儿术后细菌感染情况进行回顾性分析,总结常见细菌感染种类,并对其药物敏感试验结果、抗生素的选择进行分析。结果术后20/22(91%)患儿存在不同程度的显性及隐性感染;呼吸道(95%)及腹腔(55%)为最常见感染部位;铜绿假单胞菌、鲍曼不动杆菌为呼吸道感染常见致病菌;表皮葡萄球菌、屎肠球菌为腹腔感染常见致病菌;药敏结果显示:环丙沙星、左氧氟沙星、加替沙星及多粘菌素对铜绿假单胞菌敏感;泰能、多粘菌素及美洛配能对鲍曼不动杆菌敏感;万古霉素、利奈唑烷及替考拉宁对表皮葡萄球菌、屎肠球菌敏感。结论儿童活体肝移植术后细菌感染较为多见。其中铜绿假单胞菌、表皮葡萄球菌、鲍曼不动杆菌、屎肠球菌为常见致病菌。临床可选用时相应致细菌感染进行治疗左氧氟沙星、亚胺硫霉素、万古霉素。
Objective To investigate the types of common bacterial infections and drug sensitivity after living donor liver transplantation. Methods A retrospective analysis was performed on the bacterial infections in 22 children with LT after June 2006 to March 2009 in our hospital. The types of common bacterial infections were summarized and their drug susceptibility test results and the selection of antibiotics were analyzed . Results The postoperative 20/22 (91%) children had different degrees of dominant and recessive infection. Respiratory (95%) and abdominal cavity (55%) were the most common sites of infection. Pseudomonas aeruginosa and Baumann did not move Staphylococcus epidermidis and Enterococcus faecium were the common pathogenic bacteria of abdominal cavity infection. The results of drug susceptibility showed that the effect of ciprofloxacin, levofloxacin, gatifloxacin and polymyxin on the growth of Pseudomonas aeruginosa Sensitive to bacteria; vancomycin, linezolid and teicoplanin were sensitive to Staphylococcus epidermidis and Enterococcus faecium. Conclusions Bacterial infection after living donor liver transplantation is more common. Pseudomonas aeruginosa, Staphylococcus epidermidis, Acinetobacter baumannii, Enterococcus faecium is a common pathogen. The appropriate clinical use of bacterial infection caused by the corresponding treatment of levofloxacin, imipenem, vancomycin.