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目的:探讨ST段抬高型心肌梗死(STEMI)患者与冠状动脉造影阴性的对照组纤维蛋白原和D-二聚体含量的差异。方法:选取2007-01-2008-08间STEMI并行直接冠状动脉介入治疗术(PCI)患者161例。同时选取冠状动脉造影阴性的对照组161例,比较2组间纤维蛋白原和D-二聚体含量。结果:STEMI患者血浆纤维蛋白原含量(2.47±0.89)g/L低于对照者(2.79±0.69)g/L,差异有统计学意义(t=-3.62,P<0.01)。STE-MI患者D-二聚体含量(μg/L)的平方根(10.96±5.66)高于对照者(9.13±5.04),差异有统计学意义(t=3.07,P<0.01)。STEMI患者血浆D-二聚体含量(μg/L)与纤维蛋白原含量(g/L)比值的平方根(7.52±4.56)高于对照者(5.63±3.29),差异有统计学意义(t=4.26,P<0.01)。结论:STEMI患者的纤维蛋白原低于冠状动脉造影阴性的对照组,D-二聚体高于对照组,提示在STEMI急性期存在急性血栓形成和继发性纤溶。
Objective: To investigate the differences of fibrinogen and D-dimer between patients with ST-segment elevation myocardial infarction (STEMI) and those with negative coronary angiography. Methods: A total of 161 patients with STEMI undergoing direct coronary intervention (PCI) between January 2007 and August 2008 were selected. At the same time, 161 cases of control group with negative coronary angiography were selected, and the contents of fibrinogen and D-dimer were compared between the two groups. Results: The plasma fibrinogen content in STEMI patients was significantly lower than that in controls (2.47 ± 0.89) g / L (2.79 ± 0.69) g / L (t = -3.62, P <0.01). The square root of D-dimer level (10.96 ± 5.66) in STE-MI patients was significantly higher than that in controls (9.13 ± 5.04), the difference was statistically significant (t = 3.07, P <0.01). The square root of the ratio of plasma D-dimer to fibrinogen (g / L) in STEMI patients was 7.52 ± 4.56, which was significantly higher than that in controls (5.63 ± 3.29, t = 4.26, P <0.01). Conclusion: Fibrinogen in patients with STEMI is lower than that in patients with negative coronary angiography, and D-dimer is higher than that in the control group, suggesting acute thrombosis and secondary fibrinolysis in STEMI acute stage.