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随着肿瘤病人肠外营养(PN)和中心静脉导管的广泛应用,中心静脉导管相关性感染已成为临床令人棘手的常见院内感染。在PN输注过程中,PN液在中心静脉导管周围形成高糖和高脂微环境,有利于病原菌在置入的中心静脉导管表面黏附、生长和扩散,形成由一种或多种病原菌组成的细菌生物膜。一旦细菌生物膜形成,膜内的病原菌可抵御抗菌药物及机体免疫细胞的杀伤,造成细菌或真菌反复感染,危及病人生命。以下综述PN的应用、肿瘤病人中心静脉导管感染的特点、混合生物膜及其研究方法等,以期对中心静脉导管相关混合生物膜感染的研究提供参考。
With the widespread use of parenteral nutrition (PN) and central venous catheters in cancer patients, central venous catheter-related infections have become clinically intractable common nosocomial infections. During PN infusion, PN fluid forms a high-sugar and high-fat microenvironment around the central venous catheter, which facilitates the adherence, growth and spread of pathogenic bacteria on the surface of the inserted central venous catheter and the formation of one or more pathogenic bacteria Bacterial biofilm. Once the bacterial biofilm is formed, the pathogenic bacteria in the membrane can resist the killing of antibacterial drugs and immune cells in the body, causing repeated infections of bacteria or fungi and endangering the life of the patient. The following review of the application of PN, the characteristics of central venous catheter in patients with cancer, mixed biofilm and its research methods, in order to provide a reference for the study of central venous catheter-related mixed biofilm infection.